Alterion

Alterion contains a strain of Bacillus subtilis authorised in the EU for use in chickens for fattening and layers. 

EU category
Zootechnical additives

Functional group of additives
Gut flora stabiliser

Active substance
Bacillus subtilis (DSM 29784)

Activity in the product
NE: 1 x 10¹⁰ CFU/g
NE 50: 2 x 10⁸ CFU/g

EU approval
Minimum rate of inclusion for the below species: 1 x 10⁸ CFU/kg feed
Chickens for fattening 
Chickens reared for laying
Minor poultry species for fattening
Minor poultry species reared for laying

End of period of authorisation
Chickens for fattening: 26 March 2028
Chickens reared for laying: 26 March 2028
Minor poultry species for fattening: 20 August 2028
Minor poultry species reared for laying: 20 August 2028

EU code
4b1829

Product storage stability
No loss of viability was observed after 12 months of storage at 20°C or 6 months of storage at 37°C.

Storage stability in feed and premix
No loss of viability was observed after six months of storage of premixes supplemented with the additive. The premixes were stored at 20°C. Likewise, complete mash and complete pelleted feed were supplemented with the additive and stored for three months at 20°C. No loss of viability was observed in the complete feed.

Homogeneity    
The distribution of the additive, when added to a final feed, was tested. Analyses of ten sub-samples showed a coefficient of variation of 11% 

Heat stability
Heat stability was tested at temperatures 60, 70 and 80°C. After pelleting, the feed was analysed, and the subsequent viability was close to 90% or higher.

Compatibility claims
Compatible with diclazuril, nicarbazin, decoquinate, Lasalocid A sodium, monensin sodium, robenidine hydrochloride, maduramicin ammonium and halofuginone hydrobromide.

Carrier
Calcium carbonate, maltodextrin and silicium dioxide.

Handling
Inhalation of dust should be avoided. Gloves and goggles should be worn to reduce contact with dust.

Producer
Adisseo

EFSA (2017). Safety and efficacy of Alterion® NE (Bacillus subtilis DSM 29784) as a feed additive for chickens for fattening and chickens reared for laying. EFSA Journal 2017;15(7):4933

EU (2018). Commission Implementing Regulation (EU) No 2018/328 of 5 March 2018 concerning the authorisation of the preparation of Bacillus subtilis DSM 29784 as a feed additive for chickens for fattening and chickens reared for laying (holder of authorisation Adisseo France SAS). Official Journal of the European Union. L63/10-12

EU (2018). Commission implementing Regulation (EU) No 2018/1080 of 30 July 2018 concerning the authorisation of Bacillus subtilis DSM 29784 as a feed additive for minor poultry species for fattening and reared for laying (holder of authorisation Adisseo France SAS). Official Journal of the European Union. L194/134-136