Introduction
Avemix® XG 10 contains both beta-xylanase and beta-glucanase activity. The product is authorised for use in the EU in piglets and pigs for fattening. It is also authorised for use in chickens for fattening and other avian species.
Avemix® XG 10 is available in dry and liquid forms.
Manufacturer´s main claims
Improves animal performance due to higher digestibility of the feed
Technical specifications of Avemix® XG 10 (solid and liquid)
EU category
Zootechnical additives
Functional group of additives
Digestibility enhancers
Active substance
endo-1,4-beta-xylanase (EC 3.2.1.8)
endo-1,3(4)-beta-glucanase (EC. 3.2.1.6)
Enzymatic activity in the product
40,000 XU/g endo-1,4-beta-xylanase
9,000 BGU/g endo-1,3(4)-beta-glucanase
EU approval, minimum content
4000 XU/kg feed and 900 BGU/kg feed
Piglets (weaned)
Pigs for fattening
Turkeys for fattening
Laying hens and minor poultry species for laying
3000 XU/kg feed and 675 BGU/kg feed
Chickens for fattening
Minor poultry species for fattening
End of period of EU authorisation
Chickens for fattening: 17 March 2031
Piglets (weaned): 17 November 2021*
Pigs for fattening: 14 November 2023*
Minor porcine species for fattening other Sus scrofa domesticus: 14 November 2023*
Laying hens and minor poultry species for laying: 15 November 2022*
Minor poultry species for fattening: 15 November 2022*
Turkeys for fattening: 14 November 2023*
*: Following the provisions of Art. 14 of Reg. (EC) No 1831/2003, an application, in accordance with Article 7, has been submitted
EU code
4a9
Production organism
Xylanase derived from Trichoderma reesei (MUCL 49755)
Beta-glucanase derived from Trichoderma reesei (MUCL 49754)
Product storage stability
Solid form: When stored at 25°C or 30°C, no loss of enzymatic was observed after six months. After 13 months, the enzymatic activity was reduced to 89% beta-glucanase and 81% xylanase.
Remaining enzymatic activity in the liquid formulation stored at 25°C or 30 °C for six months:
Beta-glucanase (25°C): 75%
Xylanase (25°C): 94%
Beta-glucanase (30°C): 66%
Xylanase (30°C): 85%
Storage stability in premix and feed
Three different batches of Avemix XG 10 were supplemented to a vitamin/mineral premix. Samples of the premix were stored for three months at 25°C. After three months of storage, the remaining enzyme activities were 110% for the xylanase and 99% for the glucanase.
Three different batches of Avemix XG 10 were supplemented to a cereal-based complete feed. Samples of the feed were stored for three months at 25°C. After three months of storage, the remaining enzyme activities were 107% for the xylanase and 83% for the glucanase.
Heat stability
One batch of AveMix XG 10 was tested in a pelleting trial. At a pelleting temperature of 75°C, xylanase activity was 84%, and glucanase activity was 85 %.
Homogeneity
Both product forms were tested for their homogeneous mixing ability in the feed. Ten subsamples of a cereal-based feed supplemented with the solid or liquid form were analysed.
Coefficient of variance:
Solid: 5 %
Liquid: 14 %
Carrier
Soybean meal
Water and sorbitol
Handling
The European Commission states: "For users of the additive and premixtures, feed business operators shall establish operational procedures and organisational measures to address potential risks by inhalation and dermal contact. Where those risks cannot be eliminated or reduced to a minimum by such procedures and measures, the additive and premixtures shall be used with appropriate personal protective equipment, including breathing protection and gloves."
Manufacturer
Palital
List of references
EFSA (2009). Safety and efficacy of AveMix XG 10 (endo-1,4-beta-xylanase and endo-1,3(4)-beta-glucanase) for use as feed additive for chickens for fattening. The EFSA Journal (2009) 1094, 1-17
EFSA (2013). Scientific Opinion on the safety and efficacy of AveMix XG 10 (endo-1,4-beta-xylanase and endo-1,3(4)-beta-glucanase) as a feed additive for pigs and minor porcine species. EFSA Journal 2013; 11(4):3171
EU (2011). Commission Regulation (EU) No 335/2011 of 7 April 2011 amending Regulation (EC) No 1091/2009 as regards the minimum content of the enzyme preparation of endo-1,4-beta-xylanase produced by Trichoderma reesei (MUCL 49755) and endo-1,3(4)-beta-glucanase produced by Trichoderma reesei (MUCL 49754) as a feed additive for chickens for fattening. Official Journal of the European Union. L 94/14-16
EU (2011). Commission Implementing Regulation (EU) No 1088/2011 of 27 October 2011 concerning the authorisation of an enzyme preparation of endo-1,4-beta-xylanase produced by Trichoderma reesei (MUCL 49755) and endo-1,3(4)-beta-glucanase produced by Trichoderma reesei (MUCL 49754) as a feed additive for weaned piglets (holder of authorisation Aveve NV). Official Journal of the European Union. L281/14-15
EU (2012). Commission Implementing Regulation (EU) No 989/2012 of 25 October 2012 concerning the authorisation of endo-1,4-beta-xylanase produced by Trichoderma reesei (MUCL 49755) and endo-1,3(4)-beta-glucanase produced by Trichoderma reesei (MUCL 49754) as a feed additive for laying hens and minor poultry species for fattening and laying (holder of authorisation Aveve NV). Official Journal of the European Union. L 297/11-14
EU (2013). Commission Implementing Regulation (EU) No 1040/2013 of 24 October 2013 concerning the authorisation of a preparation of endo-1,4-beta-xylanase produced by Trichoderma reesei (MUCL 49755) and endo-1,3(4)-beta-glucanase produced by Trichoderma reesei (MUCL 49754) as a feed additive for pigs for fattening and minor porcine species for fattening other than Sus scrofa domesticus and turkeys for fattening (holder of authorisation Aveve NV). Official Journal of the European Union. L 283/46-49
EU (2021). Commission Implementing Regulation (EU) 2021/329 of 24 February 2021 concerning the renewal of the authorisation of a preparation of endo-1,4-beta-xylanase and endo-1,3(4)-beta-glucanase for chickens for fattening (holder of authorisation AVEVE NV) and repealing Regulation (EC) No 1091/2009. Official Journal of the European Union. L65/38-42