FUMzyme® contains a fumonisin esterase, which can degrade fumonisin mycotoxins. The product is authorised for use in the EU in all avian species and in pigs. The production organism was changed from Komagaetalle pastoris (DSM 26643) to a more efficient production organism Komagaetella phaffii (DSM 32159), hence the change in the EU authorisation number. 

Manufacturer´s main claims
Degrades fumonisins into non-toxic metabolites

Table 1. Technical specifications FUMzyme®

EU category Technological additives
Functional group of additives Substances for reduction of contamination of feed by mycotoxins: substances that can suppress or reduce the absorption, promote the excretion of mycotoxins or modify their mode of action 
Active substance Fumonisin esterase (EC 3.1.1.87)
Enzyme activity in the product 3000 U/g
EU approval, minimum content 1m03i:
Pigs: 10 U/kg feed
All avian species: 10 U/kg feed

1m03i:
All animal species: 40 U/kg feed 
End of period of EU authorisation 1m03i:
Pigs and all avian species, low dosage: 8 November 2028

1m03i:
All animal species: 21 March 2031
EU code 1m03 or 1m03i
Derived from microorganism 1m03: Komagataella pastoris (DSM 26643)
1m03i: Komagataella phaffii (DSM 32159)
Carrier Maltodextrin: 90%
Spent medium components: 8%
Product storage stability No loss of activity could be detected when the product was stored for 12 months at room temperature and 60% RH in the original packaging. When stored at 35°C a loss of 20% was detected.
Storage stability in feed When mixed into a premix and stored for six months at room temperature no loss of activity could be detected.
The product was also added to feed in various concentrations and stored for up to six months. After four months of storage time, no loss of activity could be detected. After six months of storage, a loss of 10% was observed.  
Heat stability For mash feed or post-pelleting application
Homogeneity Samples of piglet feed supplemented with the product were collected and analysed. The CV was 8.2%.
Handling Avoid ingestion, inhalation of dust or direct contact by applying suitable protective measures and personal hygiene
Producer Biomin

List of references

EFSA (2014). Scientific Opinion on the safety and efficacy of fumonisin esterase (FUMzyme®) as a technological additive for pigs. EFSA Journal 2014;12(5):3667

EFSA (2016). Safety and efficacy of fumonisin esterase (FUMzyme®) as a technological additive for all avian species. EFSA Journal 2016;14(11):4617

EFSA (2018). Safety and efficacy of fumonisin esterase from Komagataella phaffii (DSM 32159) as a technological feed additive for pigs and poultry. EFSA Journal 2018;16(5):5269

EU (2014). Commission Implementing Regulation (EU) No 1115/2014 of 21 October 2014 concerning the authorisation of a preparation of fumonisin esterase produced by Komagataella pastoris (DSM 26643) as a feed additive for pigs. Official Journal of the European Union. L302/52-53

EU (2017). Commission Implementing Regulation (EU) No 2017/913 of 29 May 2017 concerning the authorisation of a preparation of fumonisin esterase produced by Komagataella pastoris (DSM 26643) as a feed additive for all avian species. Official Journal of the European Union. L139/33-35

EU (2018). Commission Implementing Regulation (EU) 2018/1568 of 18 October 2018 concerning the authorisation of a preparation of fumonisin esterase produced by Komagataella phaffii (DSM 32159) as a feed additive for all pigs and poultry species. Official Journal of the European Union. L 262/34-36

EU (2021). Commission Implementing Regulation (EU) 2021/363 of 26 February 2021 concerning the authorisation of a preparation of fumonisin esterase produced by Komagataella phaffii  (DSM 32159) as feed additive for all animal species. Official Journal of the European Union. L70/3-5