BASF was the first company to introduce a phytase product for animal feed. Natuphos is authorised for use in the EU in piglets, pigs for fattening, sows and various avian species. 

The Natuphos® product range offers various products available both as granules or as a liquid product in different concentrations.

Manufacturer´s main claims
Makes phytate bound phosphorus available
Releases other nutrients like calcium, copper, zinc, magnesium and amino acids


Table 1. Technical specifications Natuphos® 5000 G

EU category Zoo-technical additive
Functional group of additves Digestibility enhancer
Active substance 3-Phytase (EC 3.1.3.8)
Phytase activity in the product 5,000 FTU/g
EU approval, minimum content No maximum content for any of the animal categories below
Piglets (suckling and weaned): 500 FTU/kg feed  
Pigs for fattening: 100 FTU/kg feed
Sows: 500 FTU/kg feed
Chickens for fattening: 375 FTU/kg feed
Chickens reared for laying/breeding: 375 FTU/kg feed
Laying hens: 250 FTU/kg feed
Turkeys for fattening: 250 FTU/kg feed
Turkeys reared for breeding: 250 FTU/kg feed
Breeding hens: 250 FTU/kg feed
Ducks: 300 FTU/kg feed
Ornamental birds and all minor avian species, other than ducks: 250 FTU/kg feed
End of period of EU authorisation 27 February 2030
EU code 4a1600
Derived from microorganism Aspergillus niger,  (CBS 101.672)
Product storage stability After 18 months the product retained approx. 90% of the activity when stored at 20°C. When stored at 35°C the activity was 84 %.
Storage stability in feed When stored in a premix for 6 months or complete feed for 3 months at 20°C the residual phytase activity was 95 %
Heat stability It is not recommended to use temperatures above 85 C during the pelleting process.
Carrier Starch, Polyethylene glycol, Polyvinyl glycol, zinc sulphate
Package size 20 kg paper bags or 350 kg big plastic bag
Handling It is assumed that the product is a potential skin sensitizer
Producer BASF

 

Table 2. Technical specifications Natuphos® 10000 G

EU category Zoo-technical additives
Functional group of additives Digestibility enhancer
Active substance 3-Phytase (EC 3.1.3.8)
Phytase activity in the product 10,000 FTU/g
EU approval, minimum content No maximum content for any of the animal categories below
Piglets (suckling and weaned): 500 FTU/kg feed  
Pigs for fattening: 100 FTU/kg feed
Sows: 500 FTU/kg feed
Chickens for fattening: 375 FTU/kg feed
Chickens reared for laying/breeding: 375 FTU/kg feed
Laying hens: 250 FTU/kg feed
Turkeys for fattening: 250 FTU/kg feed
Turkeys reared for breeding: 250 FTU/kg feed
Breeding hens: 250 FTU/kg feed
Ducks: 300 FTU/kg feed
Ornamental birds and all minor avian species, other than ducks: 250 FTU/kg feed
End of period of EU authorisation 27 February 2030
EU code 4a1600
Derived from microorganism Aspergillus niger,  (CBS 101.672)
Product storage stability After 18 months the product retained approx. 90% of the activity when stored at 20°C. When stored at 35°C the activity was 84 %.
Storage stability in feed When stored in a premix for 6 months or complete feed for 3 months at 20°C the residual phytase activity was 95 %
Heat stability It is not recommended to use temperatures above 85 C during the pelleting process.
Carrier Starch, Polyethylene glycol, Polyvinyl glucol, zinc sulphate
Package size 20 kg paper bags or 350 kg big plastic bag
Handling It is assumed that the product is a potential skin sensitizer
Producer BASF

 

Table 3. Technical specifications Natuphos® 10000 L

EU category Zoo-technical additive
Functional group of additives Digestibility enhancer
Active substance 3-Phytase (EC 3.1.3.8)
Phytase activity in the product 10,000 FTU/g
EU approval, minimum content No maximum content for any of the animal categories below
Piglets (suckling and weaned): 500 FTU/kg feed  
Pigs for fattening: 100 FTU/kg feed
Sows: 500 FTU/kg feed
Chickens for fattening: 375 FTU/kg feed
Chickens reared for laying/breeding: 375 FTU/kg feed
Laying hens: 250 FTU/kg feed
Turkeys for fattening: 250 FTU/kg feed
Turkeys reared for breeding: 250 FTU/kg feed
Breeding hens: 250 FTU/kg feed
Ducks: 300 FTU/kg feed
Ornamental birds and all minor avian species, other than ducks: 250 FTU/kg feed
End of period of authorisation 27 February 2030
EU code 4a1600
Derived from microorganism Aspergillus niger, (CBS 101.672)
Product storage stability After 9 months the product retained approx. 90% of the activity when stored at 20°C. When stored at 35°C the activity was 84 %.
Storage stability in feed When stored in complete feed for 3 months at 20°C the residual phytase activity was 95 %
Heat stability The Natuphos L product range is recommended to use when the pelleting temperature exceed 85 C. The Natuphos L should be sprayed on the pellets after the pelleting procedure.
Carrier Sorbitol, glycerol and water
Package size 1000 kg bulk container
Handling It is assumed that the product is a potential skin sensitizer
Producer BASF

 

List of references

EFSA (2006). Opinion of the scientific panel on additives and products or substances used in anmal feed and of the scientific panel on genetically modified organisms on the safety and efficacy of the enzyme preparation Natuphos (3-phytase) produced by Aspergillus niger. The EFSA Journal (2006) 369, 1-19

EU (2009). Commission Regulation (EU) No 1269/2009 of 21 December 2009 amending Regulation (EC) No 243/2007 as regards the minimum content of the feed additive in feed for pigs for fattening. Official Journal of the European Union. L 339/27

EU (2020). Commission implementing Regulation (EU) No 2020/172 of 6 February 2020 concerning the renewal of the authorisation of 3-phytase produced by Aspergillus niger (CBS 101.672) as a feed additive for piglets (weaned), pigs for fattening, sows, chickens for fattening, turkeys for fattening, laying hens, ducks and all other minor avian species, ornamental birds and the new authorisation for chickens reared for laying or for breeding purposes, turkeys reared for breeding or breeding hens and suckling piglets and repealing Regulations (EC) No 243/2007, EC (No) 1142/2007, EC (No) 165/2008, (EC) No 505/2008 and (EU) No 327/2010 (holder of authorisation BASF SE). Official Journal of the European Union. L 35/6-8

BASF (2013). Product catalog