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The Ronozyme® HiPhos product range is the newest phytase from the Novozymes DSM alliance. The scientific opinion from EFSA was published in June 2012. 
Ronozyme® HiPhos is available both in dry and liquid forms.The Ronozyme HiPhos products are available in three different concentrations.

Ronozyme® HiPhos products:

Ronozyme® HiPhos (GT) (Granulates) for pelleted feed
Ronozyme® HiPhos (M) (Granulates) for mash feed
Ronozyme® HiPhos (L) (Aqueous liquid) for post pelleting application

Manufacturer´s main claim
Increases the amount of plant phosphorus available to the animal
Substantial savings on feed costs

Table 1. Technical specifications Ronozyme® HiPhos (M)

EU Category Zootechnical additive
Functional group of additives Digestibility enhancer
Active substance 6-phytase (EC 3.1.3.26)
Phytase activity in the product 50,000 FYT/g
EU approval, minimum content Piglets, pigs for fattening, sows and poultry: 500 FYT/kg feed
Recommended maximum dose for the animal categories above: 4000 FYT/kg feed
End of period of EU authorisation 9 October 2022
EU code 4a18
Production organism Aspergillus oryzae (DSM 22594)
Donor organism Citrobacter braakii
Product storage stability Retains more than 90 % activity when stored for 12 months at 25 °C
Storage stability in feed In mash feed 92 % of the initial activity was retained when the feed was stored at 25 °C for three months
Heat stability 100 % of the phytase activity was left when the feed was pelleted at 75 °C. Higher pelleting temperatures at 85°C showed 80 % loss of activity.
Carrier Sodium sulphate, gelatinised flour, calcium carbonate, vegetable oil, cellulose, dextrin and water
Handling Should be considered as a skin sensitiser. Respiratory exposure from the solid preparation is considered unlikely
Package size 20 kg bags
Producer Novozymes


Table 2. Technical specifications Ronozyme® HiPhos (GT)

EU category Zootechnical additive
Functional group of additive Digestibility enhancer
Active substance 6-phytase (EC 3.1.3.26)
Phytase activity in the product 10,000 FYT/g
EU approval, minimum content Piglets, pigs for fattening, sows and poultry: 500 FYT/kg feed
Recommended maximum dose for the animal categories above: 4000 FYT/kg feed
End of period of EU authorisation 9 October 2022
EU code 4a18
Production organism Aspergillus oryzae (DSM 22594)
Donor organism Citrobacter braakii
Product storage stability Retains more than 90 % activity when stored for 18 months at 25 °C
Storage stability in feed In compound feed 84 to 90 % of the initial activity was retained when the feed was stored at 25 °C for three months
Heat stability More than 100 % of the phytase activity was left when the feed was pelleted at 80 °C. Higher pelleting temperatures at 90°C showed a loss of activity of 6 %. 
Carrier Sodium sulphate, cellulose and dextrin
Package size 20 kg bags
Handling Should be considered as a skin sensitiser. Respiratory exposure from the solid preparation is considered unlikely
Producer Novozymes


Table 3. Technical specifications Ronozyme® HiPhos (L)

EU category Zootechnical additive
Functional group of additives Digestibility enhancer
Active substance 6-phytase (EC 3.1.3.26)
Phytase activity in the product 20,000 FYT/g
EU approval Piglets, pigs for fattening, sows and poultry: 500 FYT/kg feed
Recommended maximum dose for the animal categories above: 4000 FYT/kg feed
End of period of EU authorisation 9 October 2022
EU code 4a18
Production organism Aspergillus oryzae (DSM 22594)
Donor organism Citrobacter braakii
Product storage stability When kept in closed container at 25°C for 12 months the product retained more than 80 % activity
Storage stability in feed In pelleted feed more than 78 % of the initial activity was retained when the feed was stored at 25 °C
Heat stability The product is intended to be used post pelleting
Handling The product is used in enclosed systems.
Producer Novozymes

List of references

EFSA (2012). Scientific opinion on safety and efficacy of Ronozyme HiPhos GT (6-phytase) as feed additive for poultry and pigs. EFSA Journal 2012; 10(6): 2730

EFSA (2012). Scientific opinion onthe  safety and efficacy of Ronozyme HiPhos M/L (6-phytase) as a feed additive for poultry and pigs. EFSA Journal 2012; 10(1): 2527

EU (2012). Commission implementing regulation  (EU) No 837/2012 of 18 September 2012 concerning the authorisation of 6-phytase (EC 3.1.3.26) produced by Aspergillus oryzae (DSM 22594)  as feed additive for poultry, weaned piglets, pigs for fattening and sows (holder of the authorisation DSM Nutritional Products). Official Journal of the European Union, L 252/7  

EU (2012). Commission implementing regulation  (EU) No 1265/2012 of 17 December 2012 amending Implementing Regulation (EU) No 837/2012 as regards the minimum activity of a preparation of 6-phytase produced by Aspergillus oryzae (DSM 22594) as feed additive for poultry, weaned piglets, pigs for fattening and sows (holder of authorisation DSM Nutritional Products). Official Journal of the European Union L 356/61

EU (2016).
Commission implementing Regulation (EU) No 2016/1881 of 24 October 2016 amending Regulation (EU) No 837/2012 as regards the minimum activity of 6-phytase produced by Aspergillus oryzae (DSM 22594) as feed additive for sows (holder of authorisation DSM Nutritional Products Ltd). Official Journal of the European Union. L 289/15-17

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