The product Actisaf® contains the special strain of yeast Saccharomyces cerevisia Sc 47. The additive is currently authorised for use in the EU in a wide range of animal species. 

Actisaf is available in three different forms; standard, powder and heat resistant

Manufacturer´s main claims

Increases milk yield and quality
Reduced occurrence of diarrhea


Technical specifications of Actisaf®

EU category Zootechnical additive
Functional group of additives Gut flora stabiliser
Active substance Saccharomyces cerevisiae (NCYC Sc 47 and CNMC I-4407)
Activity in the product 5 x 109 CFU/g
EU approval No maximum inclusion for the animal categories below.
Sows: 5 x 109 CFU/kg feed
Piglets: 5 x 109 CFU/kg feed 
Pigs for fattening: 1.25 x 109 CFU/kg feed
Dairy cows: 4 x 108 CFU/kg feed 
Dairy goats: 7 x 108 CFU/kg feed 
Dairy sheep: 7 x 108 CFU/kg 
Horses: 8 x 108 CFU/kg feed 
Dairy buffaloes: 5 x 108 CFU/kg feed
Rabbits for fattening and non-food producing rabbits: 5 x 109 CFU/kg feed
Lambs for fattening: 1.4 x 109 CFU/kg
Calves for rearing: 1.5 x 109 CFU/kg feed
End of period of authorisation Sows: 24 February 2030
Piglets: 24 February 2030
Pigs for fattening: 23 June 2029
Dairy cows: 24 February 2030
Dairy goats: 23 June 2029
Dairy sheep: 23 June 2029
Horses: 23 June 2029
Dairy buffaloes: 23 June 2029
Rabbits for fattening and non-food producing rabbits: 11 May 2022
Lambs for fattening: 23 June 2029
Calves for rearing: 22 March 2031
EU code 4b1702
Recommended dosage Pigs for fattening: 0.25 -0.5 kg/t feed
Dairy goats: 3 x 109 CFU/head/day
Ewes: 2 x 109 CFU/head/day
Horses: 1.25 - 6 x 1010 CFU/head/day
Product storage stability All three product forms have been tested for storage stability. The standard form was stored at 26°C, the powder form was stored at 25°C/60% relative humidity and 30°C/65% relative humidity in 12 or 18 months. The heat resistant version of the product was also stored for 12-18 months at 25°C/60% relative humidity. All product batches were stored in the original packaging.  There was essentially no loss of viability when the standard and powder form of Actisaf was stored for either 12 or 18 months. The heat resistant Actisaf was stable for 14 months when stored at room temperature and stable for 12 months when stored at 25°C/60% relative humidity
Storage stability in feed and premix The standard and the powder form of Actisaf were added to a mineral/vitamin premix and stored for nine months at 20°C. After nine months there was no loss of viability.  Actisaf in the standard form was added to piglet feed and stored for three months at 20°C. There was no loss of activity after three months.
Heat stability The standard and the heat resistant form of Actisaf were tested at pelleting temperatures up to 90°C. Both forms survived pelleting temperatures up to 80°C whereas the heat resistant version was slightly better at 85°C compared with the standard version.
Carrier Yeast
Package size 20 or 500 kg bags
Handling Actisaf is not expected to a skin irritant. Actisaf is furthermore not expected to be a respiratory sensitiser
Producer LeSaffre

List of references

EFSA (2007). Safety and efficacy of Biosaf Sc 47 (Saccharomyces cerevisiae) as feed additive for pigs for fattening. The EFSA Journal (2007) 585, 1-9

EFSA (2012). Scientific Opinion on the safety and efficacy of Actisaf Sc 47 (Saccharomyces cerevisiae) as a feed additive for rabbits for fattening and non-food producing rabbits. EFSA Journal 2012;10(1):2531

EU (2003). Commission Regulation (EC) No 316/2003 of 19 February concerning the permanent authorisation of an additive in feedingstuffs and the provisional authorisation of a new use of an additive already authorised in feedingstuffs. Official Journal of the European Union. L 46/15-18 

EU (2004). Commission Regulation (EC) No 1288/2004 of 14 July 2004 concerning the permanent authorisation of certain additives and the provisional authorisation of a new use of an additive already authorised in feedingstuffs. Official Journal of the European Union. L 243/10

EU (2004). Commission Regulation (EC) No 2148/2004 of 16 December 2004 concerning the permanent and provisional authorisations of certain additives and the authorisation of new uses of an additive already authorised in feedingstuff. Official Journal of the European Union. L370/24

EU (2007). Commission Regulation (EC) No 186/2007 of 21 February 2007 concerning the authorisation of a new use of Saccharomyces cerevisiae (Biosaf SC 47) as a feed additive. Official Journal of the European Union. L 63/6-8

EU (2007). Commission Regulation (EC) No 188/2007 of 23 February 2007 concerning the authorisation of a new use of Saccharomyces cerevisiae (Biosaf SC 47) as a feed additive. Official Journal of the European Union. L 57/3-5

EU (2008). Commission Regulation (EC) No 209/2008 of 6 March 2008 concerning the authorisation of a new use of Saccharomyces cerevisiae (Biosaf Sc 47) as a feed additive. Official Journal of the European Union. L 63/3

EU (2009). Commission Regulation (EC) No 232/2009 of 19 March 2009 concerning the authorisation of a new use of Saccharomyces cerevisiae NCYC Sc 47 as a feed additive for dairy buffaloes (holder of the authorisation Société Industrielle Lesaffre). Official Journal of the European Union. L 74/14-16

EU (2010). Commission Regulation (EC) No 883/2010 of 7 October 2010 concerning the authorisation of Saccharomyces cerevisiae NCYC Sc 47 as a feed additive for calves for rearing (holder of the authorisation Société Lesaffre). Official Journal of the European Union. L 265/1-3

EU (2012). Commission Implementing Regulation (EU) No 334/2012 of 19 April 2012 concerning the authorisation of a preparation of Saccharomyces cerevisiae CNCM I-4407 as a feed additive for rabbits for fattening and non-food producing rabbits and amending Regulation (EC) No 600/2005 (holder of authorisation Société Lesaffre). Official Journal of the European Union. L 108/6-8

EU (2012). Commission Implementing Regulation (EC) No 1018/2012 of 5 November 2008 amending Regulations (EC) No 232/2009, (EC) No 188/2007, (EC) No 186/2007, (EC) No 209/2008, (EC) No 1447/2006, (EC) No 316/2003, (EC) No 1811/2005, (EC) No 1288/2004, (EC) Ns 2148/2004, (EC) No 1137/2007, (EC) No 1293/2008, (EC) No 226/2007, (EC) No 1444/2006, (EC) No 1876/2006, (EC) No 1520/2007 as regards the maximum content of certain micro-organisms in complete feedingstuffs. Official Journal of the European Union L 307/56

EU (2019). Commission Implementing Regulation (EU) 2019/899 of 29 May 2019 concerning the renewal of the authorisation of Saccharomyces cerevisiae CNCM I-4407 as a feed additive for lambs for fattening, dairy goats, dairy sheep, dairy buffaloes, horses and pigs for fattening and repealing Regulations (EC) No 1447/2006, (EC) No 188/2007, (EC) No 232/2009, (EC) No 186/2007 and (EC) No 209/2008 (holder of authorisation S.I. Lesaffre). Official Journal of the European Union. L 144/32-35

EU (2019). European Union Register of feed additives pursuant to Regulation (EC) No 1831/2003. Edition 77, released 31 October 2019

EU (2020). Commission Implementing Regulation (EU) 2020/147 of 3 February 2020 concerning the authorisation of the preparation of Saccharomyces cerevisiae CNCM I-4407 as a feed additive weaned piglets, sows (in order to have a benefit for suckling piglets) and dairy cows and amending Regulations (EC) No 2148/2004, (EC) No 1288/2004 and (EC) No 1811/2005 (holder of the authorisation S.I Lesaffre). Official Journal of the European Union L31/7-9

EU (2021). Commission Implementing Regulation (EU) 2021/367 of 1 March 2021 concerning the renewal of the authorisation of a preparation of Saccharomyces cerevisiae CNCM I-4407 as a feed additive for calves for rearing and repealing Regulation (EU) No 883/2010 (holder of authorisation S.I. Lesaffre). Official Journal of the European Union. L 71/1-3