Miya-Gold® contains spores of Clostridium butyricum. The product is approved in the EU for use in piglets, chickens for fattening and other avian species.

Manufacturer´s main claim
Inhibits the growth of pathogens e.g. E. coli, Campylobacter jejuni, Salmonella typhimurium etc.

Technical specifications Miya-Gold® S and Miya-Gold® EU

EU category Zoo-technical additive
Functional group of additives Gut flora stabiliser
Active substance Clostridium butyricum (FERM BP 2789)
Activity in the product Miya-Gold® S: 5 x 108 CFU/g
Miya-Gold® EU: 1 x 1010 CFU/g
EU approval No maximum content specified for the animal categories below
Piglets: 2.5 x 108 CFU/kg feed 
Chickens reared for laying: 2.5 x 108 CFU/kg feed
Turkeys for fattening: 1.25 x 108 CFU/kg feed 
Turkeys reared for breeding: 1.25 x 108 CFU/kg feed
Minor avian species (excluding laying birds): 2.5 x 108 CFU/kg feed
End of period of authorisation Piglets: 6 May 2021
Chickens reared for laying: 14 May 2023
Turkeys for fattening: 14 November 2024
Turkeys reared for breeding: 14 November 2024
Minor avian species (excluding laying birds): 6 May 2021
EU code 4b1830
Product storage stability EFSA concludes that shelf life of at least 24 months was demonstrated.
Storage stability in feed and premix When the product was added to a vitamine/mineral premix and stored for a period of six months at 20-25°C and 40-60% relative humidity the product was stable. When added to mash or pelleted feed and stored at similar conditions the product was stable for at least three months.
Heat stability EFSA states that 50% of the viability is lost during pelleting, however, no pelleting temperature is indicated.
Compatibility claims Compatible with monensin sodium, robenidine, maduramicin ammonium, lasalocid sodium or diclazuril
Carrier Miya-Gold S: Killed brewers yeast, glucose, corn starch and aluminium silicate
Miya-Gold EU: Lactose or calcium carbonate
Handling During handling breathing protection and safety glasses should be used
Producer Miyarisan

List of references

EFSA (2009). Safety and efficacy of Miya-Gold®S (Clostridium butyricum) as feed additive for chickens for fattening. The EFSA Journal (2009) 1039, 1-16

EU (2009). Commission Implementing Regulation (EC) No 903/2009 of 28 September 2009 concerning the authorisation of the preparation of Clostridium butyricum MIYAIRI 588 (FERM-P 1467) as a feed additive for chickens for fattening (holder of the authorisation Miyarisan Pharmaceuticals Co. Ltd, represented by Mitsui & Co Deutschland GmbH). Official Journal of the European Union. L 256/26-27
EFSA (2014).
Scientific Opinion on the safety and efficacy of Miya-Gold® (Clostridium butyricum) for turkeys for fattening and turkeys for breeding. EFSA Journal 2014;12(3):3603

EU (2011).
Commission Implementing Regulation (EU) No 373/2011 of 15 April 2011 concerning the authorisation of the preparation of Clostridium butyricum FERM-BP 2789 as a feed additive for minor avian species except laying birds, weaned piglets and minor porcine species (weaned) and amending Regulation (EC) No 903/2009 (holder of authorisation Miyarisan Pharmaceutical Co. Ltd, represented by Miyarisan Pharmaceutical Europe S.L.U.). Official Journal of the European Union. L 102/10-12

EU (2013). Commission Implementing Regulation (EU) No 357/2013 of 18 April 2013 Amending Regulation (EC) No 903/2009 and implementing Regulation (EU) 373/2011 as regards the minimum content of the preparation of Clostridium butyricum (FERM BP 2789) as a feed additive for chickens for fattening and minor avian species (excluding laying birds) (holder of authorisation Miyarisan Pharmaceutical Co. Ltd. represented by Miyarisan Pharmaceutical Europe S.L.U.) Official Journal of the European Union. L 109/22

EU (2013).
Commission Implementing Regulation (EU) No 374/2013 of 23 April 2013 concerning the authorisation of a preparation of Clostridium butyricum (FERM BP-2789) as a feed additive for chickens reared for laying (holder of authorisation Miyarisan Pharmaceutical Co. Ltd represented by Miyarisan Pharmaceutical Europe S.L.U.). Official Journal of the European Union. L 112/13-14

EU (2014).
Commission Implementing Regulation (EU) No 1108/2014 of 20 October 2014 concerning the authorisation of a preparation of Clostridium butyricum (FERM BP-2789) as a feed additive for turkeys for fattening and turkeys reared for breeding (holder of the authorisation Miyarisan Pharmaceutical Co. Ltd represented by Miyarisan Pharmaceutical Europe S.L.U.). Official Journal of the European Union. L 301/16-18

EU (2019). Register of feed additives pursuant to Regulation (EC) No 1831/2003. Annex I: List of additives. Edition 11/2019 (277)