Alterion contains a strain of Bacillus subtilis authorised in the EU for use in chickens for fattening and layers. 

Main claims from the manufacturer 
Improves feed conversion ratio
Has positive effects on gut health 

Technical specifications Alterion® NE and Alterion® NE 50

EU category Zootechnical additives
Functional group of additives Gut flora stabilisers
Active substance Bacillus subtilis (DSM 29784)
Activity in the product NE: 1 x 1010 CFU per g product
NE 50: 2 x 108 CFU per g product
EU approval Chickens for fattening
Chickens reared for laying
Minor poultry species for fattening
Minor poultry species reared for laying
End of period of authorisation Chickens for fattening: 26 March 2028
Chickens reared for laying: 26 March 2028
Minor poultry species for fattening: 20 August 2028
Minor poultry species reared for laying: 20 August 2028
EU code 4b1829
Product storage stability No loss of viability was observed after 12 months of storage at 20°C or storage for six months at 37°C
Storage stability in feed and premix No loss of viability was observed after six months of storage of premixes supplemented with the additive. The premixes were stored at 20°C. Likewise, complete mash and complete pelleted feed were supplemented with the additive and stored for three months at 20°C. No loss of viability was observed in the complete feed.
Heat stability Heat stability was tested at three different temperatures: 60, 70 and 80°C. After pelleting the feed was analysed and the subsequent viability was close to 90% or higher
Homogeneity The distribution of the additive when added to a final feed was tested. Analyses of ten sub-samples showed a coefficient of variation of 11% 
Compatibility claims Compatible with diclazuril, nicarbazin, decoquinate, Lasalocid A sodium, monensium sodium, robenidine hydrochloride, maduramicin ammonium and halofuginone hydrobromide
Carrier Calcium carbonate, maltodextrin and silicium dioxide
Handling Inhalation of dust should be avoided. Gloves and goggles should be worn to reduce contact with dust
Producer/Distributor Novozymes and Adisseo

List of references

EFSA (2017). Safety and efficacy of Alterion® NE (Bacillus subtilis DSM 29784) as a feed additive for chickens for fattening and chickens reared for laying. EFSA Journal 2017;15(7):4933

EU (2018). Commission implementing Regulation (EU) No 2018/328 of 5 March 2018 concerning the authorisation of the preparation of Bacillus subtilis DSM 29784 as a feed additive for chickens for fattening and chickens reared for laying (holder of authorisation Adisseo France SAS). Official Journal of the European Union. L63/10-12

EU (2018). Commission implementing Regulation (EU) No 2018/1080 of 30 July 2018 concerning the authorisation of Bacillus subtilis DSM 29784 as a feed additive for minor poultry species for fattening and and reared for laying (holder of authorisation Adisseo France SAS). Official Journal of the European Union. L194/134-136