Introduction
Avizyme® contains three different enzymes: xylanase, subtilisin and amylase. The product is authorised for use in various avian species in the EU.
Manufacturer´s main claims
Reduces feed costs
Sustains high pelleting temperatures
Maximizes starch digestibility
Reduces anti-nutrients
Technical specifications of Avizyme® 1505
EU category
Zootechnical additives
Functional group of additives
Digestibility enhancers
Active substance
endo-1,4-beta-xylanase (EC 3.2.1.8)
subtilisin (EC 3.4.21.62)
alpha-amylase (EC 3.2.1.1)
Enzymatic activity in the product
endo-1,4-beta-xylanase: 1500 U/g
subtilisin: 20,000 U/g
alpha-amylase: 2000 U/g
EU approval, minimum content
Chickens for fattening
endo-1,4-beta-xylanase: 187.5 U/kg feed
subtilisin: 2500 U/kg feed
alpha-amylase: 250 U/kg feed
Ducks
endo-1,4-beta-xylanase: 75 U/kg feed
subtilisin: 1000 U/kg feed
alpha-amylase: 100 U/kg feed
Turkeys for fattening
endo-1,4-beta-xylanase: 300 U/kg feed
subtilisin: 4000 U/kg feed
alpha-amylase: 400 U/kg feed
Laying hens
endo-1,4-beta-xylanase: 300 U/kg feed
subtilisin: 4000 U/kg feed
alpha-amylase: 400 U/kg feed
End of period of EU authorisation
Ducks
Poultry species for fattening, reared for breeding or reared for laying (except ducks)
23 February 2035
EU code
4a10
Recommended use
For use in diets rich in arabinoxylans and beta-glucans
Production organism
endo-1,4-beta-xylanase: Trichoderma reesei (ATCC 5588)
subtilisin: Bacillus subtilis (ATCC 2107)
alpha-amylase: Bacillus amyloliquefaciens (ATCC 3978)
Product storage stability
After storage of the product for 16 months at either 20°C or 35°C, the remaining enzymatic activity was close to 100% of the initial activity.
Storage stability in premix and feed
Premixes supplemented with the product were stored at either 20°C or 35°C. After six months of storage at 20°C, there was no reduction in enzymatic activity. A storage time of three months at 35 °C reduced the activity of xylanase and protease to 86% and 89%, respectively. The amylase activity was not reduced.
Enzyme stability when supplemented to complete feed was investigated under different conditions. There was no reduction in enzyme recoveries after three months of storage at either 20°C or 35°C. After six months of storage, the recovery of subtilisin and amylase was slightly lower than 100% or exceeding. Xylanase activity was reduced to 78% and 56%, respectively, with the highest loss observed at 35°C
Heat stability
Pelleting at 80-85°C reduced the activity of xylanase, amylase and subtilisin to 98%, 74% and 97%, respectively.
Carrier
Wheat flour and calcium propionate
Package size
The product is available in 25kg multi-wall paper bags and 1000kg (tote) bulk bags.
Handling
The European Commission states: "For safety reasons: breathing protection, glasses and gloves shall be used during handling."
Manufacturer
IFF
List of references
EFSA (2009). Scientific Opinion. Safety and efficacy of Avizyme 1505 (endo-1,4-beta-xylanase), α-amylase, subtilisin) as a feed additive for chickens for fattening and ducks for fattening. The EFSA Journal (2009) 1156, 1-25
EU (2009). Commission Regulation (EC) No 1087/2009 of 12 November 2009 concerning the authorisation of an enzyme preparation of endo-1,4-beta-xylanase produced by Trichoderma reesei (ATCC PTA 5588), subtilisin produced by Bacillus subtilis (ATCC 2107) and alpha-amylase produced by Bacillus amyloliquefaciens (ATCC 3978) as a feed additive for chickens for fattening, for ducks and for turkeys for fattening (holder of authorisation Danisco Animal Nutrition, legal entity of Finnfeeds International Limited). Official Journal of the European Union. L 297/4-5
EU (2025). COMMISSION IMPLEMENTING REGULATION (EU) 2025/193 of 31 January 2025concerning the renewal of the authorisation of a preparation of endo-1,4-beta-xylanase produced with Trichoderma reesei CBS 143953, subtilisin produced with Bacillus subtilis CBS 143946 and alphaamylase produced with Bacillus amyloliquefaciens CBS 143954 as a feed additive for chickens for fattening, turkeys for fattening, ducks, and laying hens, and the authorisation of new uses of that
preparation as a feed additive for all other poultry species and categories (holder of authorisation: Genencor International B.V.) and repealing Regulation (EC) No 1087/2009 and Implementing Regulation (EU) No 389/2011. Official Journal of the European Union. http://data.europa.eu/eli/reg_impl/2025/193/oj