Introduction
FUMzyme® contains a fumonisin esterase, which can degrade fumonisin mycotoxins. The product is authorised for use in the EU in all avian species and pigs. EFSA first authorised it based on the production organism Komagaetalle pastoris (DSM 26643). The latest EFSA authorisation covers the production organism Komagaetella phaffii (DSM 32159). The minimum dosage varies depending on product approval.
Manufacturer´s main claims
Degrades fumonisins into non-toxic metabolites
Technical specifications of FUMzyme®
EU category
Technological additives
Functional group of additives
Substances for reduction of contamination of feed by mycotoxins: substances that can suppress or reduce the absorption, promote the excretion of mycotoxins or modify their mode of action
Active substance
Fumonisin esterase (EC 3.1.1.87)
Enzymatic activity in the product
3000 U/g
EU approval, minimum content per kg feed
1m03: All avian species: 15 U
1m03i: All pigs: 10 U
1m03i: All poultry species: 10 U
1m03i: All animal species: 40 U
End of period of EU authorisation
1m03: All avian species: 19 June 2027
1m03i: All pigs: 8 November 2028
1m03i: All poultry species: 8 November 2028
1m03i: All animal species: 21 March 2031
EU code
1m03
1m03i
Production organism
1m03: Komagataella pastoris (DSM 26643)
1m03i: Komagataella phaffii (DSM 32159)
Product storage stability
When the product was stored for 12 months at room temperature and 60% RH in the original packaging, no loss of activity was detected. However, when stored at 35°C, a 20% loss was detected.
Storage stability in premix and feed
No activity loss could be detected when the ingredients were mixed into a premix and stored for six months at room temperature.
The product was also added to feed in various concentrations and stored for up to six months. After four months of storage time, no activity loss could be detected. After six months of storage, a loss of 10% was observed.
Heat stability
For mash feed or post-pelleting application
Homogeneity
Samples of piglet feed supplemented with the product were collected and analysed. The CV was 8.2%.
Carrier
Maltodextrin: 90%
Spent medium components: 8%
Handling
The European Commission states: "For users of the additive and premixtures, feed business operators shall establish operational procedures and organisational measures to address potential risks resulting from their use. Where those risks cannot be eliminated or reduced to a minimum by such procedures and measures, the additive and premixtures shall be used with personal protective equipment, including breathing protection."
Manufacturer
DSM
List of references
EFSA (2014). Scientific Opinion on the safety and efficacy of fumonisin esterase (FUMzyme®) as a technological additive for pigs. EFSA Journal 2014;12(5):3667
EFSA (2016). Safety and efficacy of fumonisin esterase (FUMzyme®) as a technological additive for all avian species. EFSA Journal 2016;14(11):4617
EFSA (2018). Safety and efficacy of fumonisin esterase from Komagataella phaffii (DSM 32159) as a technological feed additive for pigs and poultry. EFSA Journal 2018;16(5):5269
EU (2014). Commission Implementing Regulation (EU) No 1115/2014 of 21 October 2014 concerning the authorisation of a preparation of fumonisin esterase produced by Komagataella pastoris (DSM 26643) as a feed additive for pigs. Official Journal of the European Union. L302/52-53
EU (2017). Commission Implementing Regulation (EU) No 2017/913 of 29 May 2017 concerning the authorisation of a preparation of fumonisin esterase produced by Komagataella pastoris (DSM 26643) as a feed additive for all avian species. Official Journal of the European Union. L139/33-35
EU (2018). Commission Implementing Regulation (EU) 2018/1568 of 18 October 2018 concerning the authorisation of a preparation of fumonisin esterase produced by Komagataella phaffii (DSM 32159) as a feed additive for all pigs and poultry species. Official Journal of the European Union. L 262/34-36
EU (2021). Commission Implementing Regulation (EU) 2021/363 of 26 February 2021 concerning the authorisation of a preparation of fumonisin esterase produced by Komagataella phaffii (DSM 32159) as feed additive for all animal species. Official Journal of the European Union. L70/3-5